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Volume 21, Number 1, 2016

Vemurafenib and concomitant stereotactic radiation for the treatment of melanoma with spinal metastases: A case report

Dinu Stefan, Hosni Popotte, Andreea Raluca Stefan, Audrey Tesniere, Aurélie Tomaszewski, Paul Lesueur, Jean-Louis Habrand, Laurence Verneuil


A 56-year-old man with BRAFV600E melanoma and spinal metastases treated with vemurafenib and stereotactic radiation showed a partial response without neurological, skin or mucosal toxicity, 8 months after completion of this combination. This case suggests that stereotactic radiation spares normal tissues and might be safer than conventional fractionated radiation with vemurafenib.

Signature: Rep Pract Oncol Radiother, 2016; 21(1) : 76-80

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