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Volume 21, Number 3, 2016

Radiotherapy for Graves’ disease. The possible role of low-dose radiotherapy

Meritxell Arenas, Sebastià Sabater, Pedro Lara Jiménez, Àngels Rovirosa, Albert Biete, Victoria Linares, Montse Belles, Julià Panés

Summary:

Immunomodulatory effects of low-dose radiotherapy (LD-RT) have been used for the treatment of several benign diseases, including arthrodegenerative and inflammatory pathologies. Graves’ disease is an autoimmune disease and radiotherapy (RT) is a therapeutic option for ocular complications. The dose recommended in the clinical practice is 20 Gy (2 Gy/day). We hypothesized that lower doses (<10 Gy total dose, <1 Gy/day) could results in higher efficacy if we achieved anti-inflammatory and immunomodulatory effects of LD-RT.

We review current evidence on the effects of RT in the treatment of Graves’ disease and the possible use of LD-RT treatment strategy.

Signature: Rep Pract Oncol Radiother, 2016; 21(3) : 213-218


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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2