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Volume 8, Number 2, 2003

Intraperitoneal administration of the labeled monoclonal anti body pemtumomab (Yttrium-90-HMFG1) in gastric cancer

Murawa P, Kobylarek R, Gracz A, Malicki J, Kierzkowski J.

Summary:

Aim: To evaluate the feasibility of treatment method (intraperitoneal administration of radiolabelled monoclonal antibody) for patients with gastric cancer. Method: A total of 15 eligible patients, with histologically proven adenocarcinoma of the stomach or gastro-oesophageal junction, who had undergone resection to remove the primary tumour mass, were enrolled in the study. Eight patients were treated with the study drug and 7 of patients were enrolled into the standard care control arm. Materials and Results: Mean blood radioactivity peaked between 36 and 48 hours, with a mean peak value of approximately 15% ID. Data previously reported on intraperitoneal Y-HMFG1 treatment of patients with ovarian cancer show peak values of 25 - 35% ID seen at 48 hour post-injection. The present results require confirmation in a large population of gastric cancer patients, but suggest that the transfer of radioactivity into the blood pool is decreased compared with the ovarian cancer patients. Conclusions: A HAMA response was detected in all patients after treatment, and there is some suggestion that is follows a bi-phasic pattern. If as hypothesised, a HAMA response provides a boost to the immune system, leading to a potential longer term benefit, then the HAMA response seen in this study following pemtumomab treatment is encouraging.

Signature: Rep Pract Oncol Radiother, 2003; 8(2) : 49-56

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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2