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Volume 6, Number 1, 2001

A prospective, randomized study to compare the value of two fractionation schemes of palliative radiotherapy for inoperable non-small cell lung cancer

Senkus-Konefka E, Jassem J, Bednaruk-Mlynski E, Dziadziuszko R, Kubrak J, Lewandowska A, Malachowski K, Wierzchowski M, Rzepecki J, Chyczewska E, Matecka-Nowak M.


A prospective, randomized study was conducted in eight Polish institutions to compare the value of two fractionation schemes of palliative radiotherapy for inoperable non-small cell lung cancer. Assessed was the impact of either treatment on the degree and duration of relief of tumor-related symptoms and on patient's performance status. Secondary endpoints included treatment side-effects, objective response and overall survival. One hundred patients were randomly assigned to the dose of 20 Gy/5x/5 days (Arm A) or 16 Gy/2x/8 days (Arm B). There were 90 men and 10 women aged between 47 and 79 (mean 66). Eighty four patients had locally advanced tumor and 16 patients had metastatic disease. Squamous cell carcinoma was diagnosed in 65 patients, adenocarcinoma - in 9 patients, large cell carcinoma - in 1 patient and unspecified non-small cell carcinoma - in 25 patients. Fifty five patients were assigned to Arm A and 45 - to Arm B. Ninety eight patients received assigned treatment whereas two patients died before the end of treatment. The final results of the study will be presented at the conference.

Signature: Rep Pract Oncol Radiother, 2001; 6(1) : 43-44

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