Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak ( for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 6, Number 1, 2001

Variants of preoperative thermoradiotherapy in locally advanced breast cancer patients

Trofimova O, Tkachev SI, Ivanov VM.


To improve treatment results of locally advanced breast cancer 60 patients with T3-4N1-2M0 TNM stage were undergone complex treatment at the Dept. of Radiotherapy of the CRC. The treatment complex included: radio- or thermoradiotherapy and polychemiohormone-therapy. All patients were subdivided into 3 groups. The first group of 20 patients received radiotherapy only, the second one (18 patients) - thermoradiotherapy, and the third group of 22 patients - thermoradoitherapy plus additional local irradiation of the primary and/or big lymphnode metastases. Radiotherapy was with 2 Gy fractions 5 times per week to the primary tumor and lymphcollectors. Total dose was 40-50 Gy. Results of the therapy were evaluated after 3-4 weeks and the patients were received a surgery. The second group of the patients received local hypertherima after 2 weeks of conventional treatment. Primary tumor and big metastatic nodes were heated. Hyperthermia was performed 2 times per week, with duration of 60 minutes, 3 hours after irradiation. Temperature in tumor was 43-45C. In the third group of patients additional boost to tumor and/or big metastatic nodes was performed with 2 Gy fractions. Total doses were the same as in first and second group, local tumor dose was 64-72 Gy. Complete or partial regression was more frequently registered in first and second group (39%, 62% respectively). In first group rate was 2%. Rate of postirradiation pathomorphosis of 3-4 grade was 35% in first group, 50% in second, 66% in third group. This data shows improvement of nearest treatment results.

Signature: Rep Pract Oncol Radiother, 2001; 6(1) : 58-59

« back


Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.