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Volume 9, Number 3, 2004

IUMPA-2: release of medroxyprogesterone acetate from the intrauterinesystem in the treatment of endometrial hyperplasia relative to the patient's body mass index BMI)

Andrzej J. Kowalski, Jakub Welfel, Jacek Suzin

Summary:

Aim: First, to develop a system of an intrauterine diaphragm with medroxyprogesterone acetate in the treatment of endometrial hyperplasia. Second, to check the distribution of this drug depending on the patient's BMI.
Material and method: The study comprised a group of 20 postmenopausal patients with histologically diagnosed simple hyperplasia treated with IUMPA-2 using endoscopic techniques hysteroscopic targeted endometrial biopsy), histological methods (bioptate assessment) and ultrasound techniques (treatment volume and endometrial measurements).
Results: In all patients investigated the rate of medroxyprogesterone acetate release increased with BMI, which had an effect on the treatment time ranging between 35 and 14 days, respectively.
Conclusions: 1) The BMI affects the rate of medroxyprogesterone acetate release from IUMPA-2. 2) In patients with a high BMI double (sequentially) application of a diaphragm should be considered.

Signature: Rep Pract Oncol Radiother, 2004; 9(3) : 73-75

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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2