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Volume 10, Number 3, 2005

Does interstitial HDR brachytherapy for breast cancer increase soft tissue fibrosis?

Anna Wronczewska, Roman Makarewicz, Renata Kabacińska, Anysja Zuchora

Summary:

Aim To analyze the physical parameters of interstitial HDR brachytherapy and their influence on the risk of soft tissue fibrosis.
Materials/Methods A retrospective analysis of 54 breast cancer patients treated between 1994–1999 in the Brachytherapy Department of the Oncological Centre in Bydgoszcz was performed. Minimum follow up period was 41 months and the maximum was 89 months. The mean follow up period was 65 months. Owing to statiscally significant differences between the groups, when compared to a normal distribution, the U Mann-Whitney non-parametrical test was used as the method for comparison.
Results Out of the nine parameters analysed, three were found to be associated with increased risk of fibrosis occurrence. Reference volumes V100, V150 and V200 showed statistically signifi cant differences (p<0.05).
Conclusions In breast conserving therapy a number of parameters influence the results of treatment. Our own studies have shown that among the risk factors responsible for fibrosis are: reference volume V100 (the volume of tissue surrounded by 100% isodose), V150 (volume of tissue surrounded by 150% isodose) and V200 (volume of tissue surrounded by 200% isodose).

Signature: Rep Pract Oncol Radiother, 2005; 10(3) : 119-123

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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2