Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak ( for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 10, Number 4, 2005

The role of oestrogen receptor b in invasive breast cancer

Maria Litwiniuk, Violetta Filas, Beata Dziekan, Jerzy Moczko, Jan Bręborowicz


Background The presence of estrogen receptor (ER) in breast cancer cell is a good prognostic factor. It is also a predictive factor used in hormonal therapy.
Aim To evaluate the expression of oestrogen receptors a and b (ERa and ERb) in the neoplastic tissues of patients with invasive breast cancer and to determine whether ERb expression may be correlated with some clinical parameters and biological markers.
Materials/Methods Paraffin embedded tissues from 67 patients with breast cancer were used in this study. Monoclonal antibodies against a oestrogen receptors, progesterone receptors (DakoCytomation) and polyclonal antibodies against b oestrogen receptors (CHEMICON) were used. The EnVision detection system was applied.
Results Expression of ERa was demonstrated in 57% of all patients, while in patients over 50 years it was higher – 71%. Expression of ERb was demonstrated in 48% of patients and this percentage was not dependent on the age of the patients. In tumours expressing ERb, expression of p53 and Ki-67 was less common. In addition, these tumours were of a lower grade of malignancy.
Conclusions Our results demonstrate a negative correlation between the expression of ERb and the expression of p53 and Ki-67. The expression of ERb may be a good prognostic indicator.

Signature: Rep Pract Oncol Radiother, 2005; 10(4) : 173-177


« back


Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.