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Volume 10, Number 4, 2005

The role of oestrogen receptor b in invasive breast cancer

Maria Litwiniuk, Violetta Filas, Beata Dziekan, Jerzy Moczko, Jan Bręborowicz

Summary:

Background The presence of estrogen receptor (ER) in breast cancer cell is a good prognostic factor. It is also a predictive factor used in hormonal therapy.
Aim To evaluate the expression of oestrogen receptors a and b (ERa and ERb) in the neoplastic tissues of patients with invasive breast cancer and to determine whether ERb expression may be correlated with some clinical parameters and biological markers.
Materials/Methods Paraffin embedded tissues from 67 patients with breast cancer were used in this study. Monoclonal antibodies against a oestrogen receptors, progesterone receptors (DakoCytomation) and polyclonal antibodies against b oestrogen receptors (CHEMICON) were used. The EnVision detection system was applied.
Results Expression of ERa was demonstrated in 57% of all patients, while in patients over 50 years it was higher – 71%. Expression of ERb was demonstrated in 48% of patients and this percentage was not dependent on the age of the patients. In tumours expressing ERb, expression of p53 and Ki-67 was less common. In addition, these tumours were of a lower grade of malignancy.
Conclusions Our results demonstrate a negative correlation between the expression of ERb and the expression of p53 and Ki-67. The expression of ERb may be a good prognostic indicator.

Signature: Rep Pract Oncol Radiother, 2005; 10(4) : 173-177

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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2