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Volume 11, Number 4, 2006

Classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy

Kazimierz Karolewski, Andrzej Michalak, Zbigniew Kojs, Jerzy Jakubowicz, Krzysztof Urbański

Summary:

Aim Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy.
Materials/Methods In the years 1985–1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation.
Results 82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor.
Conclusions In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor.

Signature: Rep Pract Oncol Radiother, 2006; 11(4) : 169-174

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http://www.sciencedirect.com/science/journal/15071367/19/2