Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 12, Number 2, 2007

Treatment of carcinoma of the oral cavity with radical and postoperative radiotherapy at the Institute of Oncology Ljubljana, 1990–1995

Primož Petrič, Primož Strojan, Marjan Budihna

Summary:

Aim To evaluate the treatment results of squamous cell carcinoma of the oral cavity treated with radical or postoperative radiotherapy at the Institute of Oncology Ljubljana, in the period 1990–1995.
Materials/Methods The medical records of patients were used to collect the data according to the predefined Data Acquisition Protocol. The impact of individual clinical and histopathological factors on the treatment outcome was evaluated by uni- and multivariate analysis.
Results Combined therapy was performed in 142 patients, and 93 patients had radiotherapy only. In each of the two subgroups, the performance status of patients was assessed as “poor” in 7% and 30%; the proportion of T1–2 tumours was 53.6% and 16.1%, and the proportion of cN0-stage tumours was 38% and 29%. The 5-year survival without local failure in surgically treated and irradiated only patients was 89% and 30%, without neck failure 85.7% and 50.3%, without any failure 79.1% and 27.5%, and overall survival 43.9% and 11.5%, respectively (all P<0.0001). In multivariate analysis, the performance status and cT-stage emerged as independent prognostic factors for all four types of survival analyzed. The type of therapy retained its independent prognostic value only in the case of survival without local failure.
Conclusions The only independent predictors of survival were performance status and cT stage, whereas the type of therapy impacted only local cure rate. The difference in survival results between the two treatments reflects primarily selection bias which occurred when patients were directed to one of the two treatment options.

Signature: Rep Pract Oncol Radiother, 2007; 12(2) : 77-86

FULL TXT (PDF: 0,15MB)

« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2