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Volume 12, Number 4, 2007

Health-related quality of life in acute myeloid leukaemia and multiple myeloma survivors undergoing autologous progenitor stem cell transplantation: a retrospective analysis

Ladislav Slovacek, Birgita Slovackova, Vladimir Pavlik, Ladislav Jebavy

Summary:

Background: Haematopoietic stem cell transplantation (HSCT) is a specifi c therapeutic method used for biomodulation antitumour therapy of haematological malignancies
and of solid tumours. It is also used for the therapy of non-tumour and hereditary
diseases.
Aim: To analyse the selected psychosocial, health and demographic aspects of quality
of life (QoL) in acute myeloid leukaemia (AML) and multiple myeloma (MM)
survivors undergoing autologous progenitor stem cell transplantation (PSCT).
Materials/Methods: The total number of AML survivors was 12 (7 male, 5 female). The total number of MM survivors was 32 (18 male, 14 female). The average age of AML survivors
was 47.5 years old. Average age of MM survivors was 60 years old. The Czech version
of the international generic European Quality of Life Questionnaire, Version EQ-5D, was used. The effect of selected psychosocial, health and demographic aspects of QoL was determined by means of analysis of variance. The descriptive analysis was used for evaluation of QoL questionnaires.
Results: The above-mentioned aspects proved statistically signifi cant dependence of QoL
(EQ-5D score and EQ-5D VAS) on age in both cohorts (p<0.01), religion in AML cohort (p<0.05), smoking abuse in both cohorts (p<0.01), level of education in AML cohort (p<0.05), increasing number of associated diseases in both cohorts (p<0.05) and type of disease (p<0.05). Global QoL in AML survivors is at a much higher level than in MM survivors undergoing autologous PSCT.
Conclusions: Low QoL correlates with increasing age of survivors treated with autologous
PSCT. QoL in survivors who underwent autologous PSCT and believed in God was higher than in survivors who were non-believers. Low QoL correlates with smoking abuse. In both cohorts of survivors we proved lower QoL in smokers in comparison with non-smokers or former smokers. Low QoL in AML survivors with low level of education, meaning survivors with elementary and apprentice level education, has been proved. Low QoL correlates with increasing number of associated diseases in both cohorts of survivors.

Signature: Rep Pract Oncol Radiother, 2007; 12(4) : 231-238

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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2