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Volume 13, Number 4, 2008

Tumour-infiltrating CD4 and CD8 T lymphocytes in breast cancer

Iwona GISTEREK, Irena FRYDECKA, Grzegorz ŚWIĄTONIOWSKI, Sebastian FIDLER, Jan KORNAFEL

Summary:

Lymphocytes are cells circulating between the blood and tissues. It has been stated that a correlation exists between immune infiltrate and breast cancer. These tumours are infiltrated by T cells, B cells, natural killer cells and macrophages. The infi ltrating T cells are of helper (CD4+) and cytotoxic (CD8+) phenotypes. Specific immunity mediated by cytolytic T lymphocytes is suspected of playing an anticancer role. It is widely known that regional lymph nodes are an important immunological defence or “barrier” against tumour expansion. Some authors have reported that in cancer patients natural killer (NK) cells and CD8+ T cells are diminished in regional lymph nodes, particularly those involved by the tumour.
In the presented study the authors review current knowledge on this problem and the possibility of using successful immunotherapy with monoclonal antibodies for breast cancer.

Signature: Rep Pract Oncol Radiother, 2008; 13(4) : 205-208

FULL TXT (PDF: 0,16MB)

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INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2