Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 13, Number 4, 2008

Irradiation of malignant exophthalmos in the course of Graves Basedow disease

Aneta L. ZYGULSKA, Barbara KOWALSKA

Summary:

AIM: To present results of irradiation of ophthalmopathy in the course of Graves-Basedow disease performed in the Radiotherapy Laboratory in University Children’s Hospital in Cracow by staff of the Oncology Clinic, Collegium Medicum Jagiellonian University (CM UJ).
MATERIAL AND METHOD: During the period of 2000–2003 therapeutic irradiation of the retrobulbar area was performed in 121 patients with malignant exophthalmos using a total dose of 20 Gy/ 10 fractions of 6 MV photonic beam in the Radiotherapy Laboratory in University Children’s Hospital in Cracow. Execution of the treatment plan was controlled by in vivo dose measurements using semiconducting detectors, MOSFET type. Radiotherapy was preceded by intravenous corticosteroid therapy (Solu Medrol) with a dose of 2g/ week for 4 weeks.
RESULTS: During the irradiation treatment 9 patients (7.4%) developed an acute post-radiation reaction of transient character. Ophthalmological control examination revealed an improvement in 97 patients (80.2%) in the form of reduction or total regression of ophthalmopathy symptoms; in 21 other patients (17.3%) stabilization was noted and progression in 3 (2.5%).
CONCLUSIONS: Radiotherapy is a well-tolerated method of ophthalmopathy treatment in the course of Graves-Basedow disease. Efficacy of radiotherapy as an exclusive method of malignant exophthalmos treatment seems to be lower in comparison to irradiation combined with corticosteroid therapy.

Signature: Rep Pract Oncol Radiother, 2008; 13(4) : 187-194

FULL TXT (PDF: 1,48MB)

« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2