Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 15, Number 5, 2010

Tracheal cancer: role of radiation therapy

Marcin Hetnał,  Alicja Alicja Kielaszek-Ćmiel, Magdalena Wolanin,
Stanisław Korzeniowski, Krzysztof Małecki,  Beata Sas-Korczyńska,  Piotr Brandys, Monika Chłosta,  Anna Kokoszka

Summary:

Purpose: To assess the results of tracheal cancer patients treatment and factors influencing prognosis.
Material and Methods: Between 1962 and 2006, fifty patients diagnosed with tracheal cancer were treated at the Centre of Oncology in Krakow. The analysis focused on locoregional recurrence-free survival, disease free survival (DFS) and overall survival (OS). Survival rates, univariate and multivariate analyses of prognostic factors were performed using the Kaplan-Meier method, the log rank test and Cox's proportional hazard method, respectively.
For over 40 years, Patients were treated using different modalities: surgery followed by radiotherapy (6%), radiotherapy (78%), chemoradiotherapy (8%), symptomatic treatment (8%).
Results: The 5-year LRRFS was 18%, DFS was 15% and OS was 17%. Gender (favoured females) was the only prognostic factor for LRRFS. For OS, the independent prognostic factors were performance status (favoured Karnofsky higher than 80), stage and year of start of the treatment (later than 1988 vs. earlier - 5-year OS 20% vs. 12%). 5-year OS in the following (strongly differentiated over the time) treatment modalities were: surgery followed by radiotherapy (66%), radiotherapy (16%), chemoradiotherapy (0%), symptomatic
treatment (0%). Of 44 patients treated with radiotherapy symptomatic partial response was observed in 32 patients and follow-up imaging studies revealed complete response in 5 patients, partial response in 25, stable disease in 4 or progressive disease in 4.
Conclusions: Radical treatment in patients in early stage and good performance status seems to be correlated with improvement of survival.
However, despite the fact that results of treatment are poor, radiotherapy offers symptomatic
improvement.

Signature: Rep Pract Oncol Radiother, 2010; 15(5) : 113-118


« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2