Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak ( for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 16, Number 3, 2011

Detection of setup uncertainties with 3D surface registration system for conformal radiotherapy of breast cancer

Letizia Deantonio, Laura Masini, Gianfranco Loi, Giuseppina Gambaro, Cesare Bolchini, Marco Krengli


Aim: To investigate the clinical application of a technique for patient set-up verification in
breast cancer radiotherapy based on a 3D surface image registration system.
Background: Accurate and reproducible patient set-up is a prerequisite to correctly deliver
fractionated radiotherapy. Various approaches are available to verify and correct patient
setup for 3D image acquisition in a radiation treatment room.
Materials and methods: The study analyzed the setup reproducibility of 15 patients affected
by breast cancer and candidates for conformal radiotherapy by using the AlignRT system
(VisionRT, London, UK). At the initial setup, electronic portal imaging device (EPID) images
were compared with Digitally Reconstructed Radiographs (DRRs) and a reference threedimensional
(3D) surface imagewas obtained by AlignRT. Surface imageswere acquired prior
to every subsequent setup procedure. The systematic and random errors along longitudinal
and vertical directions were measured and compared for the two systems.
Results: The procedure for surface registration, image acquisition and comparison with the
reference image took less than 1 min on average. The T test for systematic error showed no
significant difference between the 2 verification systems along the longitudinal (p = 0.69) and
vertical (p = 0.67) axes. The T-test for random error showed a significant difference between
the 2 systems along the vertical axis (p = 0.05).
Conclusion: AlignRT is fast, simple, non-invasive and seems to be reliable in detecting patient
setup errors. Our results suggest that it could be used to assess the setup reproducibility for
breast cancer patients.

Signature: Rep Pract Oncol Radiother, 2011; 16(3) : 77-81

« back


Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.