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Volume 16, Number 5, 2011

Prognostic role of c-met expression in breast cancer patients

Iwona Gisterek, Ewelina Lata, Agnieszka Halon, Rafal Matkowski, Jolanta Szelachowska, Przemyslaw Biecek, Jan Kornafel


Background: Hepatocyte growth factor plays an important role in tumor growth, metastasis
and angiogenesis. C-met is HGF’s high affinity receptor.
Aim: The aim of the study was to assess the correlations between c-met expression and
clinic-pathological factors in breast cancer tissues. Furthermore, the purpose of the study
was to evaluate the prognostic value of the hepatocyte growth factor receptor (HGFR, c-met)
expressions in homogenous group of breast cancer patients.
Materials and methods: Tumor samples were collected from 302 patients with breast
carcinoma treated with primary surgery. We have assessed the percentage of tumor
cells with c-met expression, the intensity of reaction and the ratio of these two
factors—immunoreactivity according to the Remmele score.
Results: We have observed no correlations between HGFR immunoreactivities and clinical
parameters (tumor size, grade, axillary lymph node status, age). In 5-year observation we
have found prognostic value of assessing c-met immunoreactivity in primary tumor.
Conclusion: Our study has revealed prognostic value of c-met. Unlike in other authors’ studies,
our patients’ group is very homogenous which might contribute to obtained results.

Signature: Rep Pract Oncol Radiother, 2011; 16(5) : 173-177

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