Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 16, Number 6, 2011

The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy

Arkadiusz Spychała, Dawid Murawa, Konstanty Korski

Summary:

Background: In spite of radical gastrectomy with resection of the lymphatic system, where
no metastases are found during histopathological examination, about 30% of patients have
relapse of the neoplastic process. This situation may be caused by micrometastases or isolated
neoplastic cells in the lymphatic system which were not identified during a standard
histopathological examination.
Aim: The aim of the study was to evaluate the clinical importance of micrometastases within
the lymphatic system in patients with gastric cancer.
Materials and methods: A group of 20 patients treated for gastric cancer were subjected to
retrospective analysis. Of all the patients who underwent surgery, a group with tumours classified
as T1 or T2 was selected. No metastases within the lymphatic system were found in the
standard evaluation – N0 mark. Paraffin-embedded blocks of lymph nodes were cut and new
specimens were made, which were then stained again by means of immunohistochemistry.
Antibodies against cytokeratin AE1/AE3 were used.
Results: A total of 319 lymph nodes were assessed in 20 patients in an H + E examination.
After the immunohistochemical examination, micrometastases within the lymphatic system
were found in 4 (20%) patients and isolated neoplastic cells in other 4 (20%) patients.
Conclusion: On the basis of numerous publications and our own material, we think that the
presence of micrometastases may be related to a worse prognosis. The clinical importance
of micrometastases within the lymphatic system in patients after total gastrectomy

Signature: Rep Pract Oncol Radiother, 2011; 16(6) : 232-236


« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2