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Volume 16, Number 6, 2011

Hyperfractionated high-dose rate brachytherapy in the treatment of oral tongue cancer

Lubos Tucek, Jiri Petera, Igor Sirák, Milan Vosmik, Helena Dolezalová,
Simona Brokesová, Miroslav Hodek, Linda Kasaová, Petr Paluska

Summary:

Background: Low-dose rate brachytherapy is a well established treatment modality of oral
cancer. Data about high-dose rate (HDR) brachytherapy are still sparse with various fractionation
schedules and heterogeneous results.
Aim: The aim of our retrospective study was to evaluate the results of HDR brachytherapy
with doses of 3Gy twice daily.
Patients and methods: Twenty patients with squamous cell tongue cancer were treated in the
years 2001–2009 by exclusive HDR BT 18×3Gy twice daily. The plastic tube technique was
used. Median follow up was 47 months (7.8–118) since brachytherapy.
Results: The local and locoregional control was 85% and 68%, respectively. Bone necrosis
developed in one case treated without mandibular shielding and soft tissue necrosis in 2
cases.
Conclusion: It can be concluded that HDR brachytherapy with 18×3Gy twice daily is safe
with promising local control. The risk of nodal recurrences is substantial.

Signature: Rep Pract Oncol Radiother, 2011; 16(6) : 243-247


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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2