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Volume 17, Number 6, 2012

Primary squamous cell carcinoma of the breast: A rare case report

Stefania Carbone, Rosabel Lobo Alvarez, Annalisa Lamacchia, Asuncion Almenar Gil, Raquel Martin Hernandez, Jose Luis Lopez Guerra, Hugo Marsiglia



Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated.


Clinical outcome assessment of a patient with squamous cell carcinoma of the breast.

Materials and methods

We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT).


With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed.


Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.

Signature: Rep Pract Oncol Radiother, 2012; 17(6) : 363-366

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