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Volume 18, Number 4, 2013

A case report of stereotactic radiosurgery in a patient with Ehlers–Danlos syndrome

Aaron D. Falchook, Timothy M. Zagar


In this report, we outline the case of a patient who has Ehlers–Danlos Syndrome (EDS) who
received two courses of CyberKnife stereotactic radiosurgery (SRS) for metastatic non-small
cell lung cancer. Patients with EDS have increased blood vessel fragility, and therefore are
subject to increased risk of bleeding. There are no published data regarding the risks of
hemorrhage associated with SRS for intracranial metastases in this patient population. The
patient described in this case report had two courses of SRS for two sites of brain metastases.
She tolerated treatment well, with no acute toxicity and good local control to date. We have
also included a discussion of published literature regarding toxicity of intracranial radiation
in patients with EDS.

Signature: Rep Pract Oncol Radiother, 2013; 18(4) : 241-244

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