Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 18, Number 4, 2013

Diagnostic value of intraoperative histopathological examination of the sentinel nodes in breast cancer and skin melanoma—Preliminary results of single centre retrospective study

Aleksander Niziołek, Dawid Murawa

Summary:

Objective: Intraoperative histopatological examination of the sentinel nodes enables selection
of patients who need dissection of the regional lymphatic system during the same operation. The aim of this study is to evaluate the diagnostic value of intraoperative
histopathological examination of the sentinel nodes in breast cancer and skin melanoma.
Intraoperative histopathology of the sentinel nodes as a diagnostic method is used in
patients with melanoma and breast cancer. Recent studies have proved it to be an effective
method for evaluating the nodes in the final histopathology. Intraoperative histopathological
examination of the sentinel nodes is not performed routinely and there is no clear position
on this issue. In this paper we try to prove that intraoperative test gives patients the simultaneous benefits of removal of regional lymph nodes metastases and earlier initiation of
adjuvant therapy.
Methods: The study comprises 137 patients with breast cancer and 35 patients with malignant skin melanoma. Sentinel nodes were intraoperatively sectioned and examined by
means of the imprint method and frozen section evaluation. The patients with positive sentinel
nodes underwent immediate dissection of regional lymph nodes. Those with negative
sentinel nodes diagnosed in the intraoperative examination, but positive in final pathologic
results, underwent subsequent dissection of regional lymph nodes.
Results: 60 sentinel lymph nodes were found in 35 patients with skin melanoma. In 3
patients, 3 sentinel lymph nodes were false negative in the intraoperative histopathological
examination. No false positive sentinel lymph nodes were found. 249 sentinel
lymph nodes were found in the intraoperative histopathological examination in 137
patients with breast cancer. There were no false positive sentinel nodes, but there
were 7 false negative sentinel nodes. In this study, only 5 (3.6%) patients with breast
cancer and 3 (8.5%) patients with skin melanoma required another regional operation. Conclusion: The method of intraoperative histopathological evaluation of the sentinel nodes
enables identification of metastases in these lymph nodes and gives a possibility to carry
out a one-step regional lymphadenectomy and start the adjuvant therapy earlier.

Signature: Rep Pract Oncol Radiother, 2013; 18(4) : 245-249


« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2