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Volume 18, Number 5, 2013

Tamoxifen in breast cancer ipse dixit in uterine malignant mixed Müllerian tumor and sarcoma—A report of 8 cases and review of the literature

Ana Luisa Cardoso Vasconcelos, Beatriz Nunes, Catarina Duarte, Vera Mendonca, Joana Ribeiro, Marília Jorge, Isabel Monteiro Grillo


Aim: Report the outcome of 8 patients (pts) with breast cancer (BC) treated with Tamoxifen
(TAM) that developed malignant mixed Müllerian tumor (MMMT) and rare uterine sarcoma
Patients and methods: Retrospective study based on data collected from the department medical records between April 1999 and September 2010 among 583 pts with endometrial cancer, 36 pts with MMMT and RUS histopathology. Among them, 8 pts underwent TAM between 4
and 10 years due to a previous diagnosis of BC; all pts were post-menopausal with regular
gynecological surveillance; 6 pts (75%) with abnormal uterine bleeding. The diagnosis of 6
pts (MMMT) and 2 pts (RUS) occurred at median interval of 8 years (range 4–12) after initial
BC treatment. Pts underwent surgical treatment and were staged as stage I (3pts), IIIA (3pts) and IIIC (2 pts) (FIGO 1988); followed by whole pelvis irradiation (50 Gy) and intracavitary HDR brachytherapy boost (24 Gy). Two pts underwent chemotherapy (CT). Overall and disease free survival was calculated by Kaplan Meier method.
Results: With a median follow-up of 47 months (range 17–130), 3 pts remain alive recurrencefree
of BC and RUS. Four pts died with distant metastasis within the first follow-up year, without BC. One pt died from non-related cancer cause. No evidence of local recurrence was found in the whole group of pts. At two years, DFS and OS were 40% and 80%, respectively.
Conclusion: As reported in the literature, TAM administration and causal effect on MMMT
and RUS in BC pts is still unknown. No reports about outcome from these specific pts were

Signature: Rep Pract Oncol Radiother, 2013; 18(5) : 251-260

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