Dear Authors,
If you believe that your paper was mistakenly rejected by other leading journals and you do not agree with final decision, the editors of Reports of Practical Oncology and Radiotherapy offer new fast track review. You may submit your manuscript to Reports of Practical Oncology and Radiotherapy together with all prior peer-reviews obtained from the other journal and your rebuttal letter. We guarantee review based decision within 72 hours from the time we will receive your manuscript.

Fast track submission process: Please submit the manuscript with all reviews and rebuttal letter by email to Dr. Michal Masternak (michal.masternak@ucf.edu) for fast review processing. To assure immediate attention the email title must to include: RPOR-fast track- Last Name First Name (of corresponding author).

Volume 18, Number 5, 2013

Late rectal and bladder toxicity following radiation therapy for prostate cancer: Predictive factors and treatment results

Rafael Fuentes-Raspall, José Maria Inoriza, Alvaro Rosello-Serrano,
Carmen Aun˜ ón-Sanza,  Pilar Garcia-Martin, Gemma Oliu-Isern

Summary:

Aim: This study aimed at investigating factors associated to late rectal and bladder toxicity
following radiation therapy and the effectiveness of Hyperbaric Oxygen Therapy (HBOT) when toxicity is grade ≥2.
Background: Radiation is frequently used for prostate cancer, but a 5–20% incidence of late
radiation proctitis and cystitis exists. Some clinical and dosimetric factors have been defined
without a full agreement. For patients diagnosed of late chronic proctitis and/or cystitis grade
≥2 treatment is not well defined. Hyperbaric Oxygen Therapy (HBOT) has been used, but its
effectiveness is not well known.
Materials and methods: 257 patients were treated with radiation therapy for prostate cancer.
Clinical, pharmacological and dosimetric parameters were collected. Patients having a
grade ≥2 toxicity were treated with HBOT. Results of the intervention were measured by
monitoring toxicity by Common Toxicity Criteria v3 (CTCv3).
Results: Late rectal toxicity was related to the volume irradiated, i.e. V50 > 53.64 (p = 0.013);
V60 > 38.59% (p = 0.005); V65 > 31.09% (p = 0.002) and V70 > 22.81% (p = 0.012). We could not
correlate the volume for bladder. A total of 24 (9.3%) patients experienced a grade ≥2. Only
the use of dicumarinic treatment was significant for late rectal toxicity (p = 0.014). A total of
14 patients needed HBOT. Final percentage of patients with a persistent toxicity grade ≥2
was 4.5%.
Conclusion: Rectal volume irradiated and dicumarinic treatment were associated to late rectal/
bladder toxicity. When toxicity grade ≥2 is diagnosed, HBOT significantly ameliorate
symptoms.

Signature: Rep Pract Oncol Radiother, 2013; 18(5) : 298-303


« back

 
INDEXED IN:

Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2