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Volume 18, Number 5, 2013

Prostate embryonal rhabdomyosarcoma in adults: Case report and review of literature

Patrizia Ciammell, Maria Galeandro, Nunziata D’Abbiero, Tamara Palmieri, Elisa Donini, Cinzia Iotti


Introduction: Prostate embryonal rhabdomyosarcoma (ERMS) is a common tumour in infants
and children, with a median occurrence age of 5 years, but it is rare in adults. It is characterized
by a high degree of malignancy, both local rapid growth with formation of large pelvic
masses, often leading to renal failure due to urethral obstruction, and systemic spread, commonly to the lungs, liver and bone. Several therapeutic approaches have been employed in
the effort to treat prostate ERMS, but all of them have failed to gain a significant survival benefit in adult patients.
Case report: We report on a case of a stage IV prostate ERMS, approached with combinedmodality treatment, with the administration of 5 courses of doxorubicin, ifosfamide and
2-mercaptoethane sulfonate sodium (mesna), and, subsequent radiotherapy to the prostatic
bed (60 Gy/30 fxs). The patient remained free of progression of disease for about 1 year to
finally experience a systemic relapse with multiple lung metastases and pleural effusion.
The patient died for metastatic disease 27 months following the initial diagnosis.
Conclusion: While it remains questionable which therapeutic approach for prostate ERMS
in adults is the most appropriate, our report demonstrates that a chemo-radiation combined
treatment can control the prostate disease, reducing the symptoms and improving the quality of life of these patients, for the most part destined to die for systemic progression of disease.

Signature: Rep Pract Oncol Radiother, 2013; 18(5) : 310-315

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