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Volume 20, Number 2, 2015

Influence of 11C-choline PET/CT on radiotherapy planning in prostate cancer

Escarlata López, Antonio Lazo, Antonio Gutiérrez, Gregorio Arregui, Isabel Núñez, Antonio Sacchetti

Summary:

Aim

To evaluate the influence of 11C-choline PET/CT on radiotherapy planning in prostate cancer patients.

Background

Precise information on the extension of prostate cancer is crucial for the choice of an appropriate therapeutic strategy.

11C-choline positron emission tomography (11C-choline PET/CT) has two roles in radiation oncology (RT): (1) patient selection for treatment and (2) target volume selection and delineation.

In conjunction with high-accuracy techniques, it might offer an opportunity of dose escalation and better tumour control while sparing healthy tissues.

Materials and methods

We carried out a retrospective study in order to analyse RT planning modification based on 11C-choline PET/CT in 16 prostate cancer patients. Patients were treated with hypofractionated step-and-shoot Intensity Modulated Radiotherapy (IMRT), or Volumetric Modulated Arc Therapy (VMAT), and a daily cone-beam CT for Image Guided Radiation Therapy (IGRT). All patients underwent a 11C-choline-PET/CT scan prior to radiotherapy.

Results

In 37.5% of cases, a re-delineation and new dose prescription occurred. Data show good preliminary clinical results in terms of biochemical control and toxicity. No gastrointestinal (GI)/genitourinary (GU) grade III toxicities were observed after a median follow-up of 9.5 months.

Conclusions

In our experience, concerning the treatment of prostate cancer (PCa), 11C-choline PET/CT may be helpful in radiotherapy planning, either for dose escalation or exclusion of selected sites.

Signature: Rep Pract Oncol Radiother, 2015; 20(2) : 104-112


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Indexed in: EMBASE®, the Excerpta Medica database, the Elsevier BIOBASE (Current Awareness in Biological Sciences) and in the Index Copernicus.

http://www.sciencedirect.com/science/journal/15071367/19/2