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Volume 20, Number 3, 2015

Tailor-made treatment combined with proton beam therapy for children with genitourinary/pelvic rhabdomyosarcoma

Hiroko Fukushima, Takashi Fukushima, Aiko Sakai, Ryoko Suzuki, Chie Kobayashi, Yoshiko Oshiro, Masashi Mizumoto, Noriko Hoshino, Chikashi Gotoh, Yasuhisa Urita, Hiroaki Komuro, Michio Kaneko, Noritoshi Sekido, Kouji Masumoto, Hideyuki Sakurai, Ryo Suma

Summary:

Background

Rhabdomyosarcoma (RMS) is one of the most common soft tissue sarcomas among children. Patients who developed genitourinary/pelvic rhabdomyosarcoma (GU/P-RMS) have a higher complication ratio and relatively poorer event free survival, with local therapy being very important. While proton beam therapy (PBT) is expected to reduce co-morbidity, especially for children, this lacks firm evidence and analysis. We analyzed GU/P-RMS children who had undergone multimodal therapy combined with PBT at a single institution.

Method

We retrospectively reviewed charts of children with GU/P-RMS treated from January 2007 to May 2013 at the University of Tsukuba Hospital who had undergone multimodal therapy with PBT.

Results

There were 5 children and their median age at diagnosis was 2.8 years (0.6–4.4 years). Primary sites were the bladder (2) and the prostate (3). All received neo-adjuvant chemotherapy and 3 underwent chemotherapy during PBT (Group Cx). All patients of Group Cx developed leukocytopenia (WBC <1000/μL). The median dose of PBT was 47.7 GyE (41.4–50.4 GyE). All patients survived by their last hospital visit (median, 36 months).

Conclusions

We analyzed multimodal treatment combined with PBT applied for GU/P-RMS. PBT was well tolerated and could be a plausible choice instead of photon therapy for this population.

Signature: Rep Pract Oncol Radiother, 2015; 20(3) : 217-222


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http://www.sciencedirect.com/science/journal/15071367/19/2